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KMID : 0356820150310010034
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Korean Journal of Head & Neck Oncology
2015 Volume.31 No. 1 p.34 ~ p.38
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Two Cases of Progressive Transformation of Germinal Centers(PTGC) in Head and Neck Area
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Han Won-Gue
Kim Tae-Min
Yoon Hee-Chul
Yum Gun-Hwee
Oh Kyoung-Ho
Kwon Soon-Young
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Abstract
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Progressive transformation of germinal centers(PTGC) is a rare benign lymph node enlargement characterized by chronic lymphadenopathy and the presence of germinal centers with fused and expanded mantles within a lymph node that are 3-5 times the size of a typical reactive follicle. Although PTGC is reported in 3.5-10% of chronic lymphadenopathy, head and neck surgeons do not often experience this condition and its clinical implications. Althoug PTGC is benign disease, it could not be excluded the association with other malignant lymphoid diseases. Therefore, periodic follow up of PTGC patient could be required. We report two cases at this study ; a 16 years old man who visited out-patient clinic due to palpable mass of right cervical area, several months ago, and a 35 years old man who visited out-patient clinic for evaluating right cervical mass. Both of two patients were diagnosed with PTGC. In this study, we focus on the clinic-pathologic features of this uncommon disease along with other literature reviews.
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KEYWORD
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Progressive transformation of germinal centers(PTGC), Nodular lymphocyte predominant Hodgkin’s disease(NLPHD), T cell rich B cell lymphoma, Nodal marginal zone B cell lymphoma, Mantle cell lymphoma
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